WebThe human ABCG2 is an important plasma membrane multidrug transporter, involved in uric acid secretion, modulation of absorption of drugs, and in drug resistance of cancer cells. Variants of the ABCG2 transporter, affecting cellular processing and trafficking, have been shown to cause gout and increased drug toxicity. In this paper, we overview the key … WebWe have uncovered the sequence of events that encompass proper folding of the ABC transporter CFTR in live cells by combining kinetic radiolabeling with protease-susceptibility assays. We found that CFTR folds in two clearly distinct stages. The first, co-translational, stage involves folding of the 2 transmembrane domains TMD1 and TMD2, plus ...
CFTR - definition of CFTR by The Free Dictionary
WebApr 28, 2024 · CFTR belongs to the ABC superfamily. Yet whereas other ABC transporters utilize the chemical energy of ATP hydrolysis to transport substrates against their … WebOct 30, 2024 · Cystic fibrosis transmembrane conductance regulator (CFTR/ABCC7) is a unique member of the ABCC/MRP family of ABC transporters, functioning as an ATP-gated chloride channel []. CFTR mutation is responsible for the genetic disease mucoviscidosis or cystic fibrosis [ [ 9 ] ]. phedre dramatist
Human Gene CFTR (uc003vjd.3) - genome.ucsc.edu
WebMar 21, 2024 · CFTR (CF Transmembrane Conductance Regulator) is a Protein Coding gene. Diseases associated with CFTR include Cystic Fibrosis and Vas Deferens, … WebApr 20, 2024 · Since CFTR is an ABC transporter, knowledge about the lipid interaction of the larger ABC transporter family may be useful to understanding CFTR. ABC transporters from many different subfamilies ... WebThe disease Cystic Fibrosis (CF) is caused by mutations in the protein called CFTR, cystic fibrosis transmembrane conductance regulator, an ABC-transporter-like protein found in the plasma membrane of animal cells. CFTR is believed to function primarily as a Cl- channel, but evidence is mounting that this protein has other roles as well. phedre english