WebJul 31, 2024 · Chloral hydrate (CH) is a central nervous system depressant and is one of the oldest sedatives (discovered in 1832). It is well absorbed orally as well as rectally and rapidly metabolized into the active … WebDec 1, 2024 · Chloral hydrate is an organic compound with the formula C2H3Cl3O2. It is a colorless solid. It has limited use as a sedative and hypnotic pharmaceutical drug. ... This has led to chloral hydrate being replaced by alternative reagents in microscopy procedures. It is, together with chloroform, a minor side-product of the chlorination of …
Chloral Hydrate - an overview ScienceDirect Topics
WebChloral hydrate has been used in human and veterinary medicine as a sedative and hypnotic drug since the mid-19th century. Chloral hydrate's effects are primarily caused … WebJustus von Liebig (1803 – 1873) Medically, chloral hydrate acts both as a sedative to calm patients and, with appropriate doses, as a hypnotic, putting the patient to sleep. These effects mean that it has been used in the past to give a sedating effect before surgery, though it has now been replaced by safer and better controlled substances. brewhouse hill wheathampstead
Chloral Hydrate - an overview ScienceDirect Topics
WebSevere insomnia (short-term use), using chloral hydrate 143.3 mg/5 mL oral solution [when insomnia is interfering with daily life and other therapies have failed] By mouth using oral … WebChloral hydrate should be given only for a short time. This medicine may become less effective after 1 or 2 weeks of use. To use as a sedative, chloral hydrate is usually taken 3 times per day after meals. To treat alcohol or drug withdrawal, chloral hydrate is usually taken every 6 hours. Follow your doctor's dosing instructions very carefully. Chloral hydrate has been a drug of choice for pediatric sedation in some facilities due to its low cost.5 However, in regards to efficacy, there are conflicting studies regarding which sedation agent is best. Numerous studies suggest there are many other effective sedative agents with more predictable … See more Between 1996 and 2009, ISMP published dozens of errors about chloral hydrate used for sedation involving mostly dosing errors, oversedation, and administration of the oral liquid by the … See more In June 2014, Nordt et al. published three cases of pediatric chloral hydrate overdoses, one a fatality, that occurred in the outpatient setting following procedural sedation.2These … See more Since 2010, ISMP has not received additional reports of errors involving pediatric sedation with chloral hydrate, which we assumed was due in large part to the 2012 … See more In addition to the risk of respiratory depression associated with most sedatives used for pediatric sedation, chloral hydrate carries several other … See more brewhouse holdings