WebTGF-β1 can serve as a driver in wound healing, tissue repair and excessive ECM accumulation. 1 TGF-β1 can also directly activate Smad signaling and trigger inflammatory and fibrotic genes overexpression. 2 Connective tissue growth factor (CTGF) is a downstream factor of the TGF-β1/Smad signaling pathway and the overexpression of … WebAug 1, 2024 · Connective tissue growth factor (also known as CTGF or CCN2) is a secreted matricellular protein that belongs to the CCN family. With wide-ranging biological …
Connective Tissue Growth Factor - an overview
WebAug 9, 2013 · Connective-tissue growth factor (CTGF) is a matricellular protein that enhances TGF-β/Smad signaling by transcriptional suppression of Smad-7 (Wahab et al., 2005. Wahab N.A. ... The expression of CTGF, Smad-2, p21, and Smad-7 in the wound area was also altered in YAP siRNA- and TAZ siRNA-treated wounds. These results … WebJun 29, 2024 · Connective tissue growth factor 2 (CTGF, CCN2), a member of the CCN family, is closely related to a variety of biological processes, including angiogenesis and … sluggishness crossword solver
Angiotensin II Induces Connective Tissue Growth Factor
WebMar 29, 2024 · SMAD translocation and ctgf expression peak levels were calculated as the mean values of the three time points around the peak, and ctgf response initiation timing was annotated and calculated at ... WebThe connective tissue growth factor (CTGF), a fibrogenic cytokine, is a downstream mediator of TGFβ/Smad-induced fibrosis. CTGF was found to be overexpressed in the filtration blebs after trabeculectomy . Moreover, CTGF activity was associated with the process of EMT and ECM synthesis by human RPE cell line ARPE19 in vitro . A possible … WebMay 14, 2014 · The TGF-β/Smad signalling pathway is one of the key pathways involved in airway remodelling. Connective tissue growth factor (CTGF), a downstream mediator of TGF-β, and transgelin, a binding and stabilising protein of the cytoskeleton, are both regulated by TGF-β1 and play an important role in airway remodelling. soka university orange county