WebApr 14, 2024 · Principal component analysis of both RNA-seq and untargeted metabolomics highlighted that MPI KO cells treated with FLT3-TKI separated from their respective Control and that the separation was ... WebJun 1, 2024 · To confirm that FLT3-ITD functionally promotes transcriptional activity at genes involved in serine biosynthesis and serine uptake, ChIP-seq using an anti-RNA …
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WebMar 13, 2024 · The SKM-1 FLT3-ITD knock-in mutant cell lines were generated using the CRISPR/Cas9 system according to the reported method. 46,47 ... For RNA-seq analysis, MV4-11 and MOLM13 cells were treated in ... WebNov 23, 2024 · In this study, to investigate mechanisms of gilteritinib sensitivity and resistance, we performed targeted sequencing (21 patients) and scRNASeq analysis (8 … can pain beat tobi
SETBP1 - American Society of Hematology
WebHowever, RNA-seq data and Chipmentation revealed non-overlapping cooperative changes in gene expression and enhancer activation between the two genotypes. FLT3 … WebOct 31, 2024 · The constitutive activation of FLT3-ITD–dependent protumor signaling pathways is crucial for the progression of this type of AML, and a number of studies have demonstrated the corresponding downstream protumor signaling factors and pathways, including ncRNAs. 47,48 For example, miR155 is an oncogene that is specifically … WebApr 9, 2024 · The receptor tyrosine kinase FLT3 with internal tandem duplications within the juxtamembrane domain (FLT3-ITD) is a poor prognostic factor; however, the prognostic significance of missense mutation in the tyrosine kinase domain (FLT3-TKD) is controversial. Furthermore, the accompanying mutations and fusion genes with FLT3 … flama font free