Phenylsulfonylfuroxan
Webirritation skin; nausea, vomiting, abdominal cramps, diarrhea, salivation; headache, dizziness, lassitude (weakness, exhaustion); rhinorrhea (discharge of thin nasal ... Twenty-three new coumarin-furoxan hybrids were synthesized, which exhibited nanomole antiproliferation activities in A2780, A2780/CDDP, MCF-7/ADR, and MDA-MB-231. Among them, compound 9showed the strongest collateral sensitivity to MCF-7/ADR with 499-fold potency compared with MCF-7.
Phenylsulfonylfuroxan
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WebHybrids of phenylsulfonylfuroxan and coumarin as potent antitumor agents. Ming Ming Liu, Xiao Yu Chen, Yao Qing Huang, Pan Feng, Ya Lan Guo, Gong Yang, Ying Chen. Research output: Contribution to journal › Article › Research › peer-review. 89 Citations (Scopus) Overview; Abstract. WebDec 11, 2024 · Among the compounds, 4-bromo-3- ( (phenylsulfonyl)-1,2,5-oxadiazole 2-oxide)-oxy-propoxy-estradiol ( 11 b) exhibited the best activity with IC 50 values of 3.58-0.0008 μM. Preliminary pharmacological studies showed that 11 b induced apoptosis and hardly affected the cell cycle of MDA-MB-231 cell line.
Web4-Hexyloxy-3-phenylsulfonylfuroxan C14H18N2O5S CID 46899560 - structure, chemical names, physical and chemical properties, classification, patents, literature ... WebMay 28, 2015 · Design, Synthesis, and Antitumor Evaluation of Novel Histone Deacetylase Inhibitors Equipped with a Phenylsulfonylfuroxan Module as a Nitric Oxide Donor - PMC Published in final edited form as: at a mole ratio of 1:1 exhibited a dramatic additive effect.
WebThe Cover Feature shows the novel hybrid of phenylsulfonylfuroxan and estradiol derivative 11b exhibited the best activity with IC 50 values of 3.58-0.0008 μ m against the MDA-MB … WebJan 1, 2024 · Compound 6, as a novel hybrid of 3-benzyl coumarin seco-B-ring derivative and nitric oxide (NO) donor phenylsulfonylfuroxan, has the potential to develop into an anticancer drug because it displays significant antiproliferation activitity for various solid cancer cell lines including non-small-cell lung cancer (NSCLC) cells. Purpose
Webphenylsulfonylfuroxan (21), which was prepared from benzene-thiol according to the reported method in ref. [23], was introduced into compounds 4 a–b, 7 a–b, 10 a–b, 13 a–b, 15, 17 and 19 in the presence of 8-diazabicyclo[5.4.0]undec-7-ene (DBU) to synthesize fifteen furoxan and estradiol derivatives
WebJun 23, 2024 · (PDF) Novel Hybrids of 3-Substituted Coumarin and Phenylsulfonylfuroxan as Potent Antitumor Agents with Collateral Sensitivity against MCF-7/ADR Novel Hybrids of 3-Substituted Coumarin and... newmarket to barrie distanceWebPhenylsulfonylfuroxan C8H6N2O4S CID 54052771 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, … newmarket to cambridge train timesWebCompound 6, as a novel hybrid of 3-benzyl coumarin seco-B-ring derivative and nitric oxide (NO) donor phenylsulfonylfuroxan, has the potential to develop into an anticancer drug … new market tn obituariesWebMay 13, 2013 · Phenylsulfonylfuroxan-anilinopyrimidine hybrid compounds inhibit the growth of tumors derived from H1975 human non-small cell lung cancer cells implanted in athymic BALB/c mice [179], while... newmarkettoday.caWebOct 28, 2014 · Sixteen furoxan-based nitric oxide (NO) releasing coumarin derivatives ( 6a – c, 8a – g, 10a, 13a, b, 15, and 17a, b) were designed, synthesized, and evaluated against … newmarket to lintonWebAug 15, 2024 · Phenylsulfonyfuroxan – -glycosylation activity. All of the compounds exhibited strong NO releasing activity and significant μM) and 95% at higher concentration (15 (pIC was 6.786). Both and vasodilatation effects … newmarket to leicesterWebApr 23, 2015 · Design, Synthesis, and Antitumor Evaluation of Novel Histone Deacetylase Inhibitors Equipped with a Phenylsulfonylfuroxan Module as a Nitric Oxide Donor ADVERTISEMENT Log In Register Cart ACS ACS Publications C&EN CAS ACS Journals ACS eBooks C&EN Global Enterprise A Accounts of Chemical Research newmarket today news