WebDec 1, 2024 · library.stanford.edu WebRobustness is an inherent property of many biological systems and a fundamental feature of evolvability ( 1 , 2 ). Robust systems can maintain their functions or traits despite a dynamically changing environment, and thus possess enhanced fitness ( 3 ).
Biological robustness Nature Reviews Genetics
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Advances in synthetic lethality for cancer therapy: cellular …
WebNov 27, 2024 · We design a simulated perturbation process to characterize the … WebHere, we discuss how to overcome these challenges and unveil the determinants of robustness and lethality of multilayer biological molecular networks, revealing the relationships between the critical structural features of a network and their functional importance in biology using a unified model. II. To define a baseline for the robustness of the real biological molecular networks, we considered multiple versions of randomized models: (1) intra-layer randomized versions, where the randomization occurs within the gene regulatory, PPI, or metabolic layers; and (2) interlayer randomized versions, where … See more According to the central dogma of molecular biology, DNA is transcribed into RNA which is then translated into protein products. Moreover, many proteins can … See more To investigate how the couplings between the gene regulatory and PPI networks contribute to defining the system structure and function, we compared the effects … See more Gene perturbations can propagate to the metabolic network through the failure of enzymes. For example, consider the gene TCF7L2, one of the most replicated type … See more In a typical scenario, to quantify the multilayer network’s robustness, one needs to perform simulations on large-scale networks, which is time-consuming and … See more khconf firestick