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WebJun 1, 2012 · Alzheimer's disease (AD) is a complex, multi-factorial neurodegenerative disease. The aggregation of soluble β-amyloid (Aβ) into fibrillar deposits is a pathological hallmark of AD. The Aβ aggregate-induced ... Aβ42 fibrillization and attenuate Aβ42-induced cytotoxicity in SH-SY5Y ... WebMay 1, 2024 · The effect of three different amyloid fragments (1−40, 1−42, 25−35) on the metabolic activity of differentiated SH-SY5Y cell cultures was assessed by the MTT test (Fig. 2).As shown in Fig. 2 A, Aβ 1–42 caused a more intense and statistically significant reduction in mitochondrial activity in the entire range of concentrations studied. WebThe stable transfected SH-SY5Y overexpressing wild type α-synuclein. The transgenic cell lines can be used as a model of neurodegenerative diseases. Creative Biolabs provides functional screening of test compounds in various cell culture models, including primary neurons from different species and cell lines. We provide customized cell culture ... crypto eddie